BUFFALO, N.Y. -- Cookie Gilchrist, one of the American Football League's first marquee players whose ferocious running style drew comparisons to that of the great Jim Brown, died of cancer Friday. He was 75.

Cookie Gilchrist led the AFL in yards rushing for three straight seasons. (Associated Press)

He died early Monday at an assisted living facility near Pittsburgh, nephew Thomas Gilchrist said. He was first diagnosed with throat cancer, and the disease spread to his prostate and colon.

"The Bills were very lucky to have procured the services of Cookie Gilchrist, who was one of the greatest fullbacks I have ever seen in all of my years in professional football," said Ralph Wilson, the 92-year-old Buffalo owner.

Gilchrist's alluring nickname belied the notion that he might easily crumble. But he was a 251-pound bruiser, and his grit and single-mindedness extended beyond the football field. He took stands against racism and wasn't afraid to demand better contracts.

Carlton Chester "Cookie" Gilchrist joined the Bills of the AFL in 1962 and spent three seasons there. He was the league's player of the year in 1962, when he had 1,096 rushing yards and a league-leading 13 touchdowns. In 1964, Gilchrist and quarterback Jack Kemp led the Bills to their first of two consecutive AFL championships.

Before joining the Bills, Gilchrist spent six years in the Canadian Football League, where he is regarded as one of its top two-way players.

Cornerback Booker Edgerson, a former Bills teammate, said Gilchrist was "just as good and maybe even better" than Brown. "He and Jim had the same outstanding abilities to play the game," he added.

Edgerson noted that Gilchrist also starred at linebacker in the CFL and wanted to play the position in Buffalo.

"Yeah, he was tough," Edgerson said. "If they would've allowed him to play linebacker, he would've kicked a lot of butt."

Gilchrist led the AFL in rushing yards for three consecutive seasons (1963 to 1965) and touchdowns (1962 to 1964). His most notable game came in Buffalo's 45-14 victory over the New York Jets in 1963. He set a then pro football record with 243 rushing yards and became just the fourth player to score five touchdowns -- one short of the record set by Ernie Nevers.

After leaving the Bills, Gilchrist spent two seasons with the Denver Broncos and one with the Miami Dolphins.

Retired Buffalo News football writer Larry Felser covered Gilchrist during his days with the Bills and still regards him as the best to play the game. Felser wrote in 2004: "Any time. Any place. Any brand of football. Cookie was, pound for pound, the greatest all-around player I ever saw. He would be a superstar in today's football."

Gilchrist also displayed a different kind of toughness. He and a group of black players boycotted the 1965 AFL All-Star Game in New Orleans after they weren't allowed into a bar and had difficulty catching taxi cabs. The game eventually was moved and played in Houston.

Gilchrist is the only player to turn down induction into the Canadian Football Hall of Fame. He cited racism and exploitation by team management.

Gilchrist had a long-running feud with Wilson after the team waived him in 1964. Gilchrist refused to return to Buffalo to attend alumni functions unless he was paid. Gilchrist and Wilson finally settled their differences last week during a phone conversation, Thomas Gilchrist said.

"I'm glad they had that conversation," Edgerson said. "When I visited him, he told me, 'I've got to bury the hatchet with Mr. Wilson.'"

Blog: Coolest nicknames This might be a surprise, but Cookie wasn't Gilchrist's birth name. In his honor, we count down the coolest nicknames of all time in the Pick Six blog. More …

On Monday, Wilson called it a "good conversation."

Edgerson called Gilchrist a unique individual, who wasn't afraid to speak out for better pay.

"He was 30 years ahead of his time," Edgerson said. "He believed in what he did, good bad or indifferent. And he would go where ever he had to make it work."

Gilchrist was a four-time AFL Pro Bowl selection. He and O.J. Simpson are the only two Bills players to score touchdowns rushing in seven consecutive games, and Gilchrist's 128 points in 1962 is the fourth-highest single-season total.

Born in Brackenridge, Pa., Gilchrist was 18 when he was lured out of high school by the Cleveland Browns. He failed to make the team and that led him to Canada, where he played six seasons with Hamilton, Saskatchewan and the final three in Toronto.

Gilchrist led Hamilton to a Grey Cup victory in 1957. He was a six-time division all-star, five times as a running back and once as a linebacker.

The Toronto Argonauts media guide refers to Gilchrist as a "charismatic and volatile free spirit, who many claim was the best all-around athlete to ever play for the Argos."

Gilchrist is survived by sons Jeffrey and Scott and daughter Christina Gilchrist, all of Toronto, and two grandchildren.

Visitation is Wednesday at the Ross G. Walker Funeral home in New Kensington, Pa. The funeral is Thursday.

Copyright 2011 by The Associated Press

Chester Gilchrist